Since ALS‐causing ANXA11 variants affecting the IDD increase protein aggregation propensity,6 we first carried out a computational analysis of the structure and aggregation propensity30, 31, 32 of ANXA11WT, ANXA11Asp40Ile, ANXA11Asp40Tyr and ANXA11Asp40Gly full‐length proteins. The gene discussed is ANXA11; the disease is amyotrophic lateral sclerosis.