HNRNPA2B1 and amyotrophic lateral sclerosis: First, p.Asp40Ile is predicted to enhance the aggregation propensity of ANXA11 to a greater extent than other pathological changes affecting this residue; second, recombinant ANXA11p.Asp40Ile showed abnormal phase separation and higher aggregation propensity than ANXA11p.Asp40Gly that causes ALS; third, the patient's fibroblasts had lower expression of ANXA11 and hnRNPA2B1 both involved in SG, and defective SG dynamics, and fourth, the patient's muscle tissue showed complex ANXA11 aggregation patterns in both the sarcoplasm and sarcolemma of the muscle fibers.