Because Duvelisib is a PI3K inhibitor and PI3K/Akt/mTOR pathway is closely related to fibroblasts activation and autophagy in the process of IPF, we detected the expression of three main related proteins of this signal pathway: PI3K, Akt, mTOR in Mlg and PPF cells by Western blotting. The gene discussed is AKT1; the disease is idiopathic pulmonary fibrosis.