CD4 and type 1 diabetes mellitus: In a separate study focused on Type 1 diabetes, citrullinated GRP78/BiPR510 containing peptides have been shown by Buitinga and co‐workers108 to bind to the shared epitope HLA‐DRB1*04:01 molecules in postcytokine‐treated human islets from type 1 diabetes patients, which were associated with the identification of higher CD4+ T‐cell frequencies directed against citrullinated GRP78 (citGRP78) epitopes.