CALR and neoplasm: But, it became clear that the translocation of CRT to the cell surface is not straight forward and it appears that several different stimuli‐dependent signalling pathways can be elicited in which CRT can reach the cell surface under pre‐apoptotic conditions63, 64, 65, 66; thus, it was proposed for surface CRT to provoke an immune response on tumour cells; it had to be released on pre‐apoptotic cells.