When VAI was analyzed as a categorical variable, compared with the top VAI quartile, subjects in the third quartile (Q3) had the highest risk for HF (OR 1.55 [95% CI 1.24–1.94]), adjusting for age, sex, race, hypertension, DM, smoking, alcohol, CHD, kidney disease, liver disease, eGFR, SBP, DBP, UA, Alb, HGB, HCT, and NLR. The gene discussed is CYGB; the disease is Hypertension.