The association remained statistically significant in all multivariate logistic regression models after adjusting for several covariates including sex, age, race, hypertension, DM, smoking, alcohol consumption, CHD, kidney disease, liver disease, eGFR, SBP, DBP, UA, Alb, HGB, HCT, and NLR (model 1, OR 1.05 [95% CI 1.03–1.07]; model 2, OR 1.02 [95% CI 1–1.05]; and model 3, OR 1.03 [95% CI 1–1.05]). The gene discussed is CYGB; the disease is liver disorder.