Recent efforts have suggested that ALDH1A1 is regulated at the posttranslational level by the Notch signalling pathway in breast cancer, which modulates ALDH1A1 acetylation through the induction of SIRT2 expression and therefore activates ALDH1A1 to promote tumorigenesis and tumour growth.83 Here, ALDH1A1 is linked to breast carcinoma.