On the one hand, ALDH18A1 positively regulates MYCN gene expression at the transcriptional and posttranscriptional levels through the miR-29b/SP1 self-regulatory loop and miRNA regulatory network, respectively, which in turn affects the division and proliferation, self-renewal, and tumorigenic capacity of neuroblastoma cells.154. The gene discussed is ALDH18A1; the disease is neuroblastoma.