With both ALDH1A1 and ALDH3A1 deletion, NUP98-HOXA10 homeodomain fusion protein can promote the development of leukaemia with B220+ and varied levels of CD11b, while NUP98-HOXA10 homeodomain fusion protein alone induces only in vitro expansion of HSCs without malignant transformation71, suggesting the important role of ALDH1A1 and ALDH3A1 in leukaemia initiation67,.72 This evidence concerns the gene ITGAM and leukemia.