ALDH1A1 and acute myeloid leukemia: Disulfiram an inhibitor of ALDH1A1 (Figure 1), may offer a new treatment strategy by selectively eradicating LSCs through the simultaneous induction of ROS-JNK and inhibition of NF-kB and Nrf276,77 and overcoming bortezomib and cytarabine resistance by inducing apoptosis and proteasome inhibition in AML.78