HOXA10 and leukemia: With both ALDH1A1 and ALDH3A1 deletion, NUP98-HOXA10 homeodomain fusion protein can promote the development of leukaemia with B220+ and varied levels of CD11b, while NUP98-HOXA10 homeodomain fusion protein alone induces only in vitro expansion of HSCs without malignant transformation71, suggesting the important role of ALDH1A1 and ALDH3A1 in leukaemia initiation67,.72