AKT1 and colorectal cancer: Other investigators have reported that knockdown of ALDH1B1 in colorectal cancer SW480 cells downregulates Wnt, Notch, and PI3K/Akt signalling and that the growth of 5-fluorouracil-resistant colorectal cancer spheroids and patient-derived organoids can be inhibited using small-molecule inhibitors of ALDH1B1130,.152