Analog 14 showed the highest antiproliferative activity in the prostate cancer cell lines DU145 and PC3, with IC50 values of 61 and 47 μM, respectively, and analog 14 also showed very low activity as a substrate for ALDH1A1 and ALDH3A1 isoforms, demonstrating the advantage of its higher selectivity.121. This evidence concerns the gene ALDH1A1 and Familial prostate cancer.