The relationship between HIC2 and RNF44 was analyzed by expression level, and the results showed that the expression of HIC2 was positively correlated with RNF44 expression in the LGG (r = 0.52, p = 6.3e‐38) and GBM datasets (r = 0.72, p = 3.0e‐25) (Figure 4G). Here, HIC2 is linked to glioblastoma.