PTPRN2 and central nervous system cancer: The relative luciferase activity in LN229 glioma cells was markedly decreased after cotransfection of HIC2 and WT‐PTPRN2‐luc or HIC2 and Mut‐E2‐luc, while luciferase activity was not affected after cotransfection of HIC2 and Mut‐E1‐luc (Figure 6F).