REN and Hypertension: Consistent with previous studies (Luo et al., 2020; Deng et al., 2019; Aslam et al., 2010), the clinical features of HCM patients with hypertension in the present study were characterized by older age, higher application of other antihypertensive drugs except β blockers, such as renin-angiotensin system inhibitors (RASIs), dihydropyridine calcium channel antagonists (DHP-CCBs) and hydrochlorothiazide.