KLK3 and Familial prostate cancer: Previously, indicators such as PSA, Gleason score, and cT were considered important prognostic indicators of TTCRPC and several studies recently confirmed the association of nPSA and TTN with prostate cancer prognosis (Tian et al., 2020; Akamatsu et al., 2019; Ali et al., 2021; Wang et al., 2018a).