EIF2B4 and leukoencephalopathy with vanishing white matter: This study generates the first EIF2B4 and EIF2B5 mutant brain organoids with human‐induced pluripotent stem cells derived from VWM patients and explores the effects of eIF2B mutations on the dynamic process of brain development from early to later stages, which provides a platform for further research on the specific pathogenesis of VWM.