When all significant univariate determinants (p < 0.05), including conventional coronary artery disease risk factors like TC, LDL, cTnI, CKMB, were entered into multivariate model, decreased MFAP4 concentration was also an independent determinant of STEMI (OR = 0.395, 95% CI 0.174–0.895, p = 0.026). This evidence concerns the gene MFAP4 and coronary artery disorder.