This trial is the first randomized, triple-blind controlled study investigating the effects of bitter almond gum consumption on the cardio-metabolic risk factors, oxidative stress, inflammatory biomarkers, LPS, CML, 8-iso-PGF2α, NO, Trp, KYN, cortisol, GLP-1, RAGE, leptin, adiponectin, ghrelin, BDNF, and mental health in women with T2DM. This evidence concerns the gene LEP and type 2 diabetes mellitus.