However, ZSCAN18 hypermethylation was not detected in normal gastric mucosal tissues or GES-1 cells, suggesting that the hypermethylation of the ZSCAN18 promoter appears to follow a chronological sequence during carcinogenesis and is involved in the early stage of the multistep process of GC [9, 13, 14]. The gene discussed is ZSCAN18; the disease is gastric cancer.