YTHDF1 and colorectal carcinoma: On the other hand, another study revealed that YTHDF1 exerts a pro-tumorigenic effect by recognizing and promoting the translation of m6A-modified FZD9 and WNT6 mRNA, leading to the aberrant activation of WNT/β-catenin signaling and ultimately promoting tumorigenicity and stem cell-like activity in CRC [77].