The average fold-downregulation of IL-6, CXCL8 and CCL2 in the presence of various inhibitors and siRNA across multiple experiments and multiple tissues shows that FGFRs are potent inducers of neuroinflammatory mediators in primary microglia and could be important novel pathogenic determinants in Lyme neuroborreliosis. The gene discussed is CCL2; the disease is Lyme disease.