NOC2L was found to be recruited by Enhancer of zeste homolog 2 (EZH2) and cooperate with EZH2 through physical interaction to promote the methylation of H3K27 in the vicinity of forkhead box O3 (FOXO3) promoter region [51], leading to the downregulation of tumor suppressor FOXO3 in breast cancer cells [51]. The gene discussed is FOXO3; the disease is breast cancer.