After ischemic stroke in white matter, microglia and macrophages are activated, then release a large number of pro-inflammatory cytokines such as tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1 β) and produce matrix metalloproteinases (MMPs) such as MMP-9 that disrupt the integrity of the blood–brain barrier [7], thereby promoting infiltration of immune cells such as T lymphocytes. This evidence concerns the gene TNF and ischemic stroke.