In the end, we managed to formulate a signature of 7 IRGs for the prognosis of sepsis patients: − 0.465 × CCL5 + 0.215 × DEFA4 − 1.487 × NFYC + 1.055 × ESR1 − 0.737 × TNFRSF8 − 0.228 × CX3CR1 + 1.003 × SERPINA3. This evidence concerns the gene DEFA4 and Sepsis.