In another aspect, TGFβ1 concentrations in serum and BALF were significantly decreased in patients with early initiation of CRRT compared to those with late initiation of CRRT on day 2 and day 7, and early initiation of CRRT is associated with favorable clinical outcomes in ARDS patients, which might be due to the reduced serum and BALF TGFβ1levels through CRRT [28]. This evidence concerns the gene TGFB1 and acute respiratory distress syndrome.