MMP12 and neoplasm: Our immune infiltration analysis found that MMP12 showed a positive linear relationship with nTreg and iTreg, indicating that high expression of MMP12 may mean increased nTreg and iTreg, promoting tumor growth, suggesting that MMP12 may be a negative factor for immunotherapy, and our TIDE The analysis found that the higher the expression of MMP12, the higher the TIDE score and the worse the immunotherapy effect, which is consistent with the above findings.