ABCB1 and urinary bladder carcinoma: In a study attempting to resensitize T24R2 cisplatin-resistant bladder cancer cells to the drug via MDR1 inhibition, it was discovered that inhibiting Ets1 activity, which is an important transcription factor controlling MDR1 transcription as well as increasing chemotherapy resistance, resuscitated cisplatin activity in T24R2 cells [83].