TET2 gene a master regulator of hematopoiesis, which commonly gets dysfunction in CLL, and other hematopoietic cancers as inhibit potent CAR T cell properties of immunotherapy and finding Tet2 negative specific cells via above mechanisms could positively impact on tumor immune response [61, 62]. The gene discussed is TET2; the disease is hematopoietic and lymphoid cell neoplasm.