CD19 and B-cell chronic lymphocytic leukemia: To treat several hematologic malignancies and solid tumors includes acute lymphoblastic leukemia (ALL), diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), mantle cell lymphoma (MCL), and multiple myeloma (MM) CAR T cell therapy has been used in recent decades [24, 63] First attempt of CAR T cells targeted B cell antigen CD19 to treat CLL.