CD19 and graft versus host disease: By inactivation of TCR by CRISPR Cas9-ribonucleoparticles (RNPs) for CD19 targeted CAR reduce allo-reactivity due to the reduction of endogenous TCR expression and SB-CD19-28z.CAR T/TCR KO T cells for a increase memory phenotype thus improve the chances of using CAR T cells for therapy with reduce GVHD [60].