TGFB1 and neoplasm: Nevertheless, Jung et al. [84] knocked out both DGKα and DGK ζ isoforms using CRISPR in CAR T cells which led to heightened TCR signaling and sustained and robust effector function in vitro, while in vivo findings reported that DGK deficiency resulted in remarkable tumor eradication of U87MGvIII glioblastoma tumors and resistance to immunosuppressive molecules including prostaglandin E2 and TGF-β.