ACTL6A and cancer: At the same time, the predicted inhibition of upstream regulators such Actl6a (an oncogenic driver in many human cancers, Jian et al. 2021) and Egfr (a major regulator of proliferation and differentiation in epithelial cells, Ramírez Moreno and Bulgakova 2022) points towards reduced cell survival and proliferation in the mammary gland of shaved mice.