NR1H3 and fatty liver disease: Specifically, the α-ketoglutarate-dependent Jumonji C (JmjC) domain-containing demethylase KDM4B (also known as JMJD2B) has been reported to promote hepatic steatosis by regulating the adipogenic transcription factor, PPARγ2, and lipogenic transcription factor, LXRα [28, 29].