Taken together, the results of different studies indicate that KDM4B plays a critical role in PPARγ2-dependent fatty acid uptake and storage as well as LXR-mediated lipogenesis by removing the repressive histone marks, H3K9me2 and H3K9me3, on their corresponding promoters, contributing to the formation of liver steatosis. The gene discussed is PPARG; the disease is Hepatic steatosis.