KMT2D and Hepatic steatosis: In a recent study, KMT2D was demonstrated to direct overnutrition-induced steatosis in mice through the activation of the nuclear receptor peroxisome proliferator activated receptor γ isoform 2 (PPARγ2), the master adipogenic transcription factor that stimulates the uptake of fatty acids and the formation of lipid droplets, thereby promoting hepatic steatosis.