The overexpression of KDM4B in HepG2 cell line and in high-fat diet-fed mice reduced the enrichment of H3K9me2 and H3K9me3 on the promoter of PPARγ2, thereby stimulating its expression as well as the expression of PPARγ2 steatotic target genes (fatty acid translocase, CD36; fatty acid binding protein 4, FABP4; perilipin 2, PLIN2; fat-specific protein 27/cell death-inducing DFFA-like effector C, CIDEC) that promote the progression of NAFLD [28]. This evidence concerns the gene PPARG and metabolic dysfunction-associated steatotic liver disease.