Besides mono- and di-methylation of H3K9 mediated by KMT1C, the suppressor of variegation 39 homolog 2 (KMT1B; also known as Suv39H2) catalyses histone H3 lysine 9 trimethylation and has also been implicated in the pathogenesis of NASH. The gene discussed is SUV39H2; the disease is metabolic dysfunction-associated steatohepatitis.