The repression of KDM3A using the appropriate knockdown under hypoxic conditions inhibited HCC cell proliferation whereas its upregulation under the same conditions induced HCC cell growth due to a reduction of the demethylation of H3K9 at the promoter of the adrenomedullin gene and the consequent overexpression of this target [81, 82]. Here, ADM is linked to hepatocellular carcinoma.