Our study aimed to assess whether different intensities of glycemic targets for pregnant women with GDM influence the maternal cardiometabolic markers of triglycerides, cholesterol, CRP, leptin, and adiponectin, and infant cardiometabolic, growth, and inflammatory markers of cord plasma C-peptide, leptin, adiponectin, and insulin-like growth factor (IGF). The gene discussed is LEP; the disease is gestational diabetes.