ACE2 and serum lipopolysaccharide activity: In this study, we tested the hypotheses that (i) preeclamptic fetal programming refashions renal vasoconstrictor and hemodynamic profiles of endotoxemia in adult offspring, (ii) fetal reprogramming is influenced by the offspring sex and gestational Ang1-7 supplementation, and (iii) molecular entities of the ACE/ACE2/AT1 receptor pathway mediate the PE-LPS interactions.