On the other hand, genes inversely correlated with activity scores point to the upregulation of genes involved in B cell and T cell receptor signalling (MALT1, PTPN6, NFATC2, MAP4K1, REL), EMT (ITGB4), fibroblast growth factor activity (KLB), fatty acid uptake/metabolism (FABP2, SUGCT, LTA4H), glucose utilisation (GNPDA1, NEUROD1, SCGN, SLC2A12, SH2D3A, PIK3C2G), DNA repair (BARD1), and gene biomarkers for hepatocellular carcinoma (HCC) (HELLS, PIWIL2, TROAP). This evidence concerns the gene REL and hepatocellular carcinoma.