In the attempt to identify the cellular processes involving an ERK5-dependent YAP activation, we first analyzed the effect of ERK5 inhibition in cell-extracellular matrix (ECM) adhesion dynamics where the modulation of transcriptional activity of YAP has been well documented, both in the physiological and pathological cell response to mechanical stimuli as well as in cancer progression [45]. The gene discussed is YAP1; the disease is cancer.