These data, illustrated by the promoter interactome of the DDX41 (Fig. 7D), a DEAD box RNA helicase associated with B-ALL and other blood malignancies49, demonstrates that the use of a four-cutter restriction enzyme increases the power to detect short-range interactions and compromises the detection of the long-range ones. The gene discussed is DDX56; the disease is precursor B-cell acute lymphoblastic leukemia.