We investigated the trafficking of neuronal tPA in cultured neurons prepared from the THY-Tau22 (Tau22) mouse model of AD, previously characterized by an hyperphosphorylation of Tau, that ends up in unhooking of microtubules, Tau aggregates, paired helical filaments and neurofibrillary tangles (NFTs) [34] (Fig. 7A). Here, PLAT is linked to Alzheimer disease.