A high level of ROS in NSCs783 mediated the breakage of diselenide bonds to release simvastatin,784 which promoted NSCs to secrete BDNF.785 The ASO against Let-7b downregulated Let-7b miRNA, thereby inhibiting the differentiation of NSCs through the upregulation of TLX.776 PNPs-treated NSCs were injected into the brain under the guidance of a stereotaxic instrument to promote BDNF secretion by exogenous NSCs in AD lesions, thereby facilitating the self-repair of neurons by promoting the proliferation of endogenous NSCs. Here, BDNF is linked to Alzheimer disease.