MMP2 and neoplasm: PTX inhibits tumor cell mitosis by mediating abnormal microtubule function, thereby promoting apoptosis.720,721 Matrix metallopeptidase-2 (MMP-2) is highly expressed in GBM.722 Activation of MMP-2 contributes to GBM invasion by promoting tumor neovascularization.723,724 Wang et al. encapsulated the PTX and complexes formed by RNAi pDNA against MMP-2 with PEI in PLGA microfibers.725 The microfibers synergistically treated GBM through stereotactic local administration.