In addition, DAG (CDAGRKQKC) specifically binds to connective tissue growth factor (CTGF), which is highly expressed in the brain of AD patients and promotes the cellular uptake of the vectors in AD lesions.236 Tet1 (HLNILSTLWKYR) has a high affinity for trisialoganglioside (GT1b) on neurons, enabling the treatment of NDs.237,238 The cyclic RGD sequence (cRGD), which is widely used in the treatment of tumors, binds specifically to αvβ3 and αvβ5 integrins on the endothelial cells of angiogenic tumor vessels to facilitate vector targeting of brain tumors.239–241. This evidence concerns the gene CCN2 and Alzheimer disease.