The miRNA-loaded PNPs inhibited GBM proliferation and synergistically enhanced the response to standard-of-care γ radiation after local administration.734 Roundabout homolog 1 (Robo1),735 yes-associated protein 1 (YAP1),736 sodium-potassium-chloride cotransporter (NKCC1),737 survivin,738 and EGFR739 are all tumor therapeutic targets. Here, ROBO1 is linked to glioblastoma.