Shi et al. also co-loaded siSTAT3 and TMZ via exosomes.664 Heme oxygenase 1 (HMOX1) is highly expressed on GBM cell membranes.665 Chemotherapy further promotes the expression of HMOX1 and may promote GBM resistance to chemotherapy.665–668 Therefore, the HMOX1 targeting peptide (HSSP, VQDSAPVETPR) could be employed as a ligand to target GBM. This evidence concerns the gene HMOX1 and glioblastoma.