Interestingly, in a mouse model of CCl4-induced liver fibrosis, siHSP47-loaded AA-T3A-C12 LNP also remarkably outperformed MC3 LNP in silencing HSP47 (65% vs. 31%), reducing collagen deposition and alleviating liver fibrosis despite their comparable liver accumulation (Figs. 5 and 6a, b). Here, SERPINH1 is linked to Hepatic fibrosis.