SERPINH1 and Hepatic fibrosis: In a mouse model of carbon tetrachloride (CCl4)-induced liver fibrosis, HSP47 siRNA (siHSP47)-loaded AA-T3A-C12 LNP achieved ~65% knockdown and dramatically reduced liver fibrosis, which significantly outperformed the benchmark DLin-MC3-DMA (MC3) LNP.