BC bound to NCL and the 3′UTR of IMPAD1 and recruited hnRNPD, hnRNPK and IGF2BP1 to modulate AS of IMPAD1 to produce the non‐protein‐coding IMPAD1‐203 variant and induce EMT process leading to EGFR‐TKI resistance. The gene discussed is IGF2BP1; the disease is breast cancer.