SERPINE1 and neoplasm: Expanding the protein-protein interaction analysis (S1–S3 Figs) revealed additional networks for the whole cohort: one network included ITGAV, LRP1, PLAT, and SERPINE1, all associated with tumour progression, cell invasion and metastasis; and the other included CDK1/2, NCAPG, PKB and CCN family genes, all associated with tumour progression and cell proliferation (S1 Fig).