Among the 39 genes upregulated within all cancers, two protein-protein interaction networks were observed (Fig 6): one composed primarily of cancer-specific antigens including GAGE1, MAGEB2, MAGEC2 and SSX1; the other included cytokines (interferons and interleukins such as IFNA1, IFNB1, IL1, IL17, IL22) and ARG1, with a sub-network including CRP, FN1, PLAU and complement genes. This evidence concerns the gene PLAU and cancer.