In particular, SNAP-25 polymorphisms, gene expression, and protein concentration, have been associated with different neurological and non-neurological diseases, including Alzheimer’s disease (AD) [9–12], Parkinson’s disease (PD) [13], neurodevelopmental disorders such as Autism and Borderline Intellectual Functioning [14–16], Attention Deficit and Hyperactivity Disorder (ADHD) [17], type 2 diabetes [18, 19] and sarcopenia [20]. Here, SNAP25 is linked to Alzheimer disease.