Reassuringly, for both individuals, the number of ATAC-seq reads that originated from the chromosome with the C allele was 3 times higher than the number of reads originating from the chromosome with the T allele (donor1 – 5T:15C; donor2 – 4T:12C; p-value = 0.021), providing support for the notion that the T allele reduces the activity of TRPM1 promoter in the macular region, the affected tissue in AMD (Fig 6E). The gene discussed is TRPM1; the disease is age-related macular degeneration.