OTX2 and age-related macular degeneration: Finally, by intersecting the identified LHX2-OTX2 cis-regulatory map with published eQTL and ATAC-seq data from human RPE, we reveal a causal noncoding genetic variant for AMD and demonstrate that it acts by altering TRPM1 expression in the RPE through modulation of LHX2 binding to its promoter.