RDH5 and age-related macular degeneration: Interestingly, of the 15 putative causal risk genes for AMD identified by eQTL analysis, the expression level of 3 genes—TRPM1, TSPAN10, and RDH5—is highly enriched in RPE [48], the site of early disease pathology, thereby, specifying these genes as key players in molecular pathways that underlie AMD pathogenesis.