Finally, by intersecting the identified LHX2-OTX2 cis-regulatory map with published eQTL and ATAC-seq data from human RPE, we reveal a causal noncoding genetic variant for AMD and demonstrate that it acts by altering TRPM1 expression in the RPE through modulation of LHX2 binding to its promoter. This evidence concerns the gene TRPM1 and age-related macular degeneration.