RPE65 and age-related macular degeneration: Of these, our ChIP-seq analyses pinpointed 71 (36%) as direct LHX2 target genes and 134 (69%) as direct OTX2 target genes (based on the proximity of the OTX2-binding site to the genes’ TSS), including OTX2 itself and several genes that are mutated in inherited forms of retinal degeneration (e.g., RPE65, BEST1, MITF, TYR, MYO7A, and TIMP3) as well as genes associated with elevated risk to AMD (e.g., COL8A1, TRPM1).