Although harboring a monoallelic PDCD1 deletion, these cells expressed functional PD-1 and other exhaustion markers, demonstrating a moderately exhausted phenotype, while the PD-1 blockade released proximal TCR signals and led to the disinhibition of oncogenic PKCθ/NF-κB signaling, resulting in lymphoma progression and deterioration of the patient. The gene discussed is NFKB1; the disease is lymphoma.