Down-regulated miR-34a expression is often observed in NSCLC, contributing to tumorigenesis by attenuating p53-dependent apoptosis [78]; miR-486 is considered an ideal biomarker in cancer diagnosis [79] targeting components related to insulin growth factor (IGF) signaling and functioning as a tumor suppressor in NSCLC [72]. The gene discussed is IGF1; the disease is non-small cell lung carcinoma.