More specifically, they found that HSP70+/TSG101+ EVs from HPV-negative oral cancer (PCI-13 and PCI-30) cells reduced dendritic cell maturation while EVs from HPV-positive oral cancer (UMSCC2, UMSCC47, SCC90) cells upregulated maturation of dendritic cells, which contributes to improved outcomes of HPV-positive HNC patients [54]. The gene discussed is TSG101; the disease is lip and oral cavity carcinoma.