Herein, it is our purpose to provide a concise review of current evidence associated with the role of FLVCR1-AS1, and FBXL19-AS1 in different cancers, by firstly discussing the abnormal expression of these lncRNAs in patient samples, followed by the description of their molecular mechanism of action and overall impact on signaling pathways leading to cancer development and progression. The gene discussed is FLVCR1; the disease is cancer.