Our results provided scientific data on the rate of mutations in the LMP1-EBV gene for NPC tissue biopsy and the frequency of HLA alleles in Vietnamese patients, as well as on the relationship between the 30 bp gene deletion mutation of LMP1-EBV and HLA-B*15 alleles in NPC patients, which has not previously been studied, either in Vietnam or the world. This evidence concerns the gene HLA-B and nasopharyngeal carcinoma.