Figure 1 shows the relationship between normal liver and the SUVmax range of suspicious avid lesions on PSMA PET. Of the 49 lesions assessed, the average SUVmax in normal liver was 6.1 (SD 2.2, IQR 5.5–6.2) whereas in suspicious PSMA avid lesions, the average SUVmax was 10.8 (SD 4.9, IQR 8.0–11.6) with cross-over between groups. The difference in the mean SUVmax was statistically significant (p score = 0.0002). This may provide a threshold SUVmax for assessment of suspicious lesions. An example of a PSMA positive HCC is shown in Figure 2. The gene discussed is FOLH1; the disease is hepatocellular carcinoma.