A study of HCT116 cell lines with reintroduced TGFBR2 signalling found that the MSI driver mutation of TGFBR2 can influence the protein packaging of sEVs whereby a later study by the same group identified 48 small-EV-specific proteins, such as fibronectin (FN1), which plays a pro-tumorigenic role in CRC [56], to be regulated in a TGFBR2-dependent manner [53,54]. Here, TGFBR2 is linked to colorectal carcinoma.