-23 proteins were altered in FTD vs. HC (increased: APOL1, C3, CTSH, EIF5A, MYH2, S100A8, SUSD5, WDR1; decreased: C1S, C7, CILP2, COMP, CRTAC1, EFEMP1, FBLN1, GSN, HSPG2, IGHV1, ITIH2, PROS1, SHBG, UMOD, VASN)-14 proteins were altered in ALS vs. HC (increased: APOL1, CKM, CTSH, IGHG1, IGKC, MYH2; decreased: C7, COMP, CRTAC1, EFEMP1, FBLN1, GSN, HSPG2, SHBG) [116]. This evidence concerns the gene C3 and frontotemporal dementia.