TARDBP and amyotrophic lateral sclerosis: Instead, in regard to TDP-43, the group of Rogelj [91] indicated that TDP-43 is an important regulator of RNA metabolism and intracellular transport in ALS–FTD, observing that proteins related to cellular processes (Ran-binding protein 1, DNA methyltransferase 3 alpha and chromogranin B) were downregulated upon TDP-43 knockdown.