Moreover, protein acetylation seems to be differentially regulated: for example, the glial fibrillary acid protein (a GFAP-component of the filament of astrocytes that plays a role in astrocyte-neuron interaction) was found to be heavily acetylated and upregulated in an ALS patient’s spinal cord, suggesting a potential neuroprotective effect of histone deacetylase inhibitors [121]. Here, GFAP is linked to amyotrophic lateral sclerosis.