CD274 and esophageal squamous cell carcinoma: Yagi et al38 found that PD-L1 positivity was significantly associated with worse OS, while the opposite result was reported by Hatogai et al.39 Our previous report found that PD-L1 positivity in TCs of pre-CRT ESCC tissues was significantly associated with a lower pCR rate and worse RFS.40 However, the current study failed to find a significant association between PD-L1 expression and pCR.