Finally, novel SSc specific autoantibodies have been described in about 10% of the former called “seronegative” SSc patients: anti-elF2B, anti-RuvBL1/2 complex, anti-U11/U12 RNP and anti-BICD2 depict specific SSc subtypes with severe organ complications [12]. The gene discussed is RUVBL1; the disease is systemic sclerosis.