These findings were later supported by a detailed analysis of 2754 SSc patients from the EULAR scleroderma trials (EUSTAR) database where Ingegnoli et al. reported that the “Late” pattern was present in 47% of ATA+ patients vs. 28% of ACA+ patients (p < 0.05) whereas the “Early” and “Active” patterns were more frequent in ACA+ than in ATA+ patients (44% vs. 28%, p < 0.05). The gene discussed is ATM; the disease is scleroderma.