In vitro expanded γδ T cells by BrHPP, or zoledronate plus IL-2 or IL-15, exerted cytotoxicity against autologous MM cells as well as MM cell lines [144,145,146,147,148], but this effect was abrogated by γδ T cell depletion [149] or by the mevastatin-induced upstream blockade of the mevalonate pathway [150]. This evidence concerns the gene IL2 and Miyoshi myopathy.