Indeed, monocytic MDSCs (CD11b+ CD33+ CD15- CD14+ HLA-DR low/−) and polymorphonuclear MDSCs (CD11b+ CD33+ CD15+ CD14- HLA-DR low/−) progressively increased from pre-neoplastic conditions through MM at diagnosis to relapse and correlated with poor OS [86]. The gene discussed is CD33; the disease is Miyoshi myopathy.