Our mRNA profiling study also confirmed the expression of several general neuronal markers (TUBB3) and cell type specific markers (cholinergic, dopaminergic, and serotonergic neurons); moreover, we found that different neuronal markers had opposite correlations with the enrichment scores of tumor microenvironment-related gene sets, implying that distinct neuronal types might play different modulating roles in microenvironment formation. The gene discussed is TUBB3; the disease is neoplasm.