INS and Insulin resistance: Third, the adipose tissue of obese patients with insulin resistance has a lower mechanistic target of rapamycin complex 2 (mTORC2) signaling, secondary to high MCP1 expression and the higher presence of macrophages [52]; mTORC2 plays an important role in regulating energy balance and weight and appears to be regulated by insulin, growth factors and the quantity of nutrients [54].