Furthermore, detailed PPI analysis found that the genes are engaged in a variety of pathways, including bacterial infection response, inflammatory response, negative regulation of the viral process, cytokine-mediated signaling pathway, cytokine production, cytokine receptor binding, chemokine receptor binding, cellular response to tumor necrosis factor, response to LPS, toll-like receptor signaling pathway, antifungal humoral response, TNF, regulation of T-cell cytokine production and SARS-Cov2 innate immune evasion and cell-specific immune response (Figure 5). This evidence concerns the gene TNF and bacterial infectious disease.