Previous studies, not stratified for IDH mutation status or other molecular markers, have tried to elucidate optimal treatment and patient outcome but most likely included IDHwt glioblastomas (formerly astrocytoma IDHwt) which are much more common in the elderly than IDHmut glioma and show a dismal prognosis [10]. Here, IDH2 is linked to astrocytoma (excluding glioblastoma).